The results and groups of risk after removal of pituitary adenomas.
Andrey J.Grigoriev, Pavel L.Kalinin.
European Congress of Endocrinology 3-7 September, Goteborg, Sweden, 2005.
National Research Center for Endocrinology. Moscow. Russia.
Burdenko neurosurgical institute. Moscow. Russia.
Materials and metods:
We retrospectively analysed all patients, were first time operated from 1980 to 1997. 1981 patients (59% female), the mean age was 39 (4-92) years. 387 patients (20%) were operated by transcranial, 775 (80%) by transnasal approach.
Comparing results of surgical treatment it is obvious, that the best results are given transsphenoidal surgery: mortality was 1,9% (24 from 1231 patients); after transcranial surgery mortality was 6,3% (47 from 750 patients).
The greatest mortality in group of patients was more senior than 60 years - 7,5 %, in group of patients with expressed invasion a tumour in the basis of a skull - 22,7 %, in group of patients with huge adenomas (> 60 mm) - 20,2 %.
Principal causes of death of patients were infringements of brain blood circulation on haemorragic type at 12 patients (16,9 %), infringements of brain blood circulation on ischemic type at 9 (12,7 %), on mixed at 11 (15,5 %), meningitises at 13 (18,3 %), somatic problems at 8 (11,3 %) etc.
The group of patients there was combination huge pituitary adenoma and advanced age have a high risk of mortality. The most often reason of lethal outcomes were infringements of brain blood circulation on haemorragic to type and meningitises.